Research

INDIVIDUAL RESEARCHER

Dana R. Crawford , Ph.D.
Assistant Professor
e-mail: crawfod@mail.amc.edu

Education

1983 - Ph.D. from Dartmouth

Current Research

Dr. Crawford's laboratory is primarily involved in the modulation of mammalian gene expression by oxidative and nitrosative stress. He has identified a number of novel genes, designated "ADAPTS", and is characterizing their function and possible clinical use in stress-related diseases and disorders. One of these genes, ADAPT78 (RCAN1), has become a major laboratory research focus. Its protein product inhibits calcineurin, an intracellular protein important to calcium signaling. As such, Adapt78 is thought to be important in regulating many calcium-dependent cellular functions such as immune response and brain function. The laboratory is currently assessing the role that Adapt78 plays in calcineurin-related pathologies including immune system dysfunction, Alzheimer's disease, Down syndrome, and brain inflammation. The laboratory is also involved in combining the above projects with Diet and Nutrition as a translational approach to treating these pathologies. These studies use healthy dietary supplements such as plant polyphenols and broccoli sulforaphane as novel alternative approaches to treating pathologies; for example, to achieve immunosuppression (for autoimmune and transplant patients) and to treat Down syndrome and Alzheimer's disease (by modulating specific disease-causing genes). This approach is healthy and cost-effective, and improves compliance in patients. Dr. Crawford is also a member of two area inter-institutional organizations: the Capital Region Cancer Research (CRCR) group, for which he chairs the steering committee; and ALZNYCAP, an Alzheimer's Center of Excellence.

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References

1. Michtalik, M.J., Narayan, A.V., Bhatt, N., Lin, H.Y., Mulligan, M.T., Zhang, S., and Crawford, D.R. 2004. Multiple oxidative stress-response members of the Adapt78 family. Free Rad. Biol. Med. 37: 454-462



2. Narayan, A.V., Stadel, R., Hahn, A.B., Bhoiwala, D.L., Cornielle, G., Sarazin, E., Koleilat, I., and Crawford, D.R. 2005. Redox response of the endogenous calcineurin inhibitor Adapt78. Free Rad. Biol. Med. Free Rad. Biol. Med. 39: 719-727.



3. Kerri S. Kluetzman, Ana V. Perez, and Dana R. Crawford (2005) DSCR1 (ADAPT78) lethality: Evidence for a protective effect of trisomy 21 genes? Biochem. Biophys. Res. Comm. 337: 595-601.



4. Amber N. Mitchell, Lalithapriya Jayakumar, Issam Koleilat, Jiang Qian, Christine Sheehan, Dipti Bhoiwala, Shazneen F. Hushmendy, Janet M. Heuring, and Dana R. Crawford. 2007. Brain expression of the calcineurin inhibitor RCAN1 (Adapt78). Arch. Biochem. Biophy. 467: 185-192.



5. Dee Van Riper, Lalithapriya Jayakumar, Nicholas Latchana, Dipti Bhoiwala, Amber N. Mitchell, Jonathan W. Valenti, and Dana R. Crawford. 2008. Regulation of Vascular Function by RCAN1 (ADAPT78). Arch. Biochem. Biophys. 472:43-50.