Research

INDIVIDUAL RESEARCHER

Katharine Herrick-Davis , Ph.D.
Professor
e-mail: daviskh@mail.amc.edu

Education

1988 - Ph.D. from Albany Medical College

Current Research

The long-term objective of our research is to gain a better understanding of the physiological roles of serotonin (5-HT) in the central nervous system. 5-HT produces its actions by binding to specific receptors located in cell membranes. To date, 14 different 5-HT receptors have been cloned. Drugs that interact with 5-HT receptors are prescribed for anxiety, depression, schizophrenia, appetite regulation, migraine, and emesis. Drugs of abuse, such as LSD, stimulate 5-HT receptors in the brain. We use radioligand binding assays to develop new drugs specific for 5-HT receptors expressed in recombinant cell lines and receptor autoradiography to verify the location of receptors in the brain. Current molecular biology techniques are used to create mutations in 5-HT receptor genes to understand receptor structure and function. In addition, we use RT-PCR to clone new receptors and mRNA differential display to study gene expression following receptor stimulation.

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References

1. Egan, C., Grinde, E., DuPre, A., Roth, B.L., Hake, M., Teitler, M. and Herrick-Davis, K. (2000) Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex model at serotonin 5-HT2A and 5-HT2C receptors. Synapse 35:144-150.



2. Herrick-Davis, K., Grinde, E. and Niswender, C.M. (1999) Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction. J. Neurochem. 73:1711-1717.



3. Niswender, C.M., Copland, S.C., Herrick-Davis, K., Emeson, R.B. and Sanders-Bush, E. (1999) RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences consitutive activity. J. Biol. Chem. 274:9472-9478.



4. Egan, C., Herrick-Davis, K. and Teitler, M. (1998) Agonist activity of LSD and lisuride at cloned 5-HT2A and 5-HT2C receptors. Psychopharmacol. 136:112-116.



5. Egan, C., Herrick-Davis, K. and Teitler, M. (1998) Creation of a constitutively activated state of the 5-HT2A receptor: inverse agonist activity of antipsychotic drugs. J.Pharm.Exp.Ther. 861:136-139.